Acetic Anhydride → HCID 67745337, compound

HRID 375485Notes

Reaction equation

HRID 375485 reaction equation
C(OC(=O)C)(=O)C.[C:8]1([C:14]2([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:19][CH2:18][S:17](=O)[CH2:16][CH2:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1(C)C=CC=CC=1>[C:8]1([C:14]2([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:15]=[CH:16][S:17][CH2:18][CH2:19]2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 67745330HCID 67745330, compound

Product 1

HCID 67745337HCID 67745337, compoundYield 83.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3.95 cm3 of acetic anhydride are added to a suspension of 2.7 g of 4,4-diphenyltetrahydrothiapyran 1-oxide in 30 cm3 of anhydrous toluene. The mixture is refluxed for 20 hours and concentrated to dryness at 60° C. under reduced pressure (2.7 kPa and then 0.13 kPa). The oily residue is crystallized from diisopropyl oxide, the crystals are drained and dried. 2.1 g of 3,4-dihydro-4,4-diphenyl-2H-thiapyran are obtained in the form of white crystals; melting point 78° C.

Workup

  1. temperatureThe mixture is refluxed for 20 hours
  2. concentrationconcentrated to dryness at 60° C. under reduced pressure (2.7 kPa
  3. customThe oily residue is crystallized from diisopropyl oxide
  4. customdried

Sources & evidence

ORD record
ord-d4e360728783413687354eb3f0b50cfe
Source dataset
uspto-grants-1996_01
Patent number
US05484942

Reaction notes

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