HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3,5-Difluorophenyl)-3-hydroxy-1-(2,2,2-trifluoroethyl)pyrrolidine → HCID 19935834, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3,5-Difluorophenyl)-3-hydroxy-1-(2,2,2-trifluoroethyl)pyrrolidine | HCID 19935800 | — |
| Reactant | 1-Methyl-6-sulfanyl-1,2,3,4-tetrahydroquinolin-2-one | HCID 22413759 | — |
| Product | HCID 19935834 | HCID 19935834 | 30% |
Reaction Steps
Using an analogous procedure to that described in Example 6, 6-mercapto-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 3-(3,5-difluorophenyl)-3-hydroxy-1-(2,2,2-trifluoroethyl)pyrrolidine to give 3-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-3-hydroxy-1-(2,2,2-trifluoroethyl)pyrrolidine as a gum in 30% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420298 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-e6a65cfeddf74f3f8d5e2ba73b4ec9b9 |
| Source note | uspto-grants-1995_05 |