HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Mercaptoacetanilide → 3-[3-(4-Acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Mercaptoacetanilide | HCID 70777 | — |
| Reactant | 3-(3,5-Difluorophenyl)-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine | HCID 19935817 | — |
| Product | 3-[3-(4-Acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine | HCID 19935846 | 54% |
Reaction Steps
Using an analogous procedure to that described in Example 6, 4-mercaptoacetanilide was reacted with 3-(3,5-difluorophenyl)-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine to give 3-[3-(4-acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine in 54% yield, m.p. 127°-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420298 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-24f1aee3b6fd4676991b1100df3f8a97 |
| Source note | uspto-grants-1995_05 |