Methanol → HCID 10981608, compound

Participants

Reaction Steps

17β-cyclopropyloxy-androst-4-en-3-one (9.70 g, 29.5 mM), potassium tert-butoxide (7.0 g, 62.4 mM), and isopropyl nitrate (2.99 ml) are reacted by the method of Example 1 to yield 17β-cyclopropyloxy-4-nitroandrost-4-en-3-one, m.p. 137°-38° C. (methanol) IR (CHCl3) , 1695, 1622(m) , 1535, 1373 cm-1MS(CI) 374(100%, M+10, 316(20%, M+1-c-C3H5 -O) 1H-NMR (CDCl3) 0.38-0.61(4H, m), 0.80(3H, s, C18 -Me), 1.29(s, C19 -Me), 3.25-3.33(1H, m, cyclopropyl-CHO), 3.44(1H, t, C17 -H) .

Provenance & Evidence