HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 10640035, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 17beta-(Cyclopropyloxy)androst-5-en-3beta-ol | HCID 14882764 | — |
| Reactant | Jones' reagent | HCID 131709961 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 10640035 | HCID 10640035 | 57.2% |
Reaction Steps
A solution of 17β-cyclopropyloxy-androst-5-en-3β-o1 (19.36 g, 58.9 mM) in acetone (1.9 L) previously cooled to -3° C. is treated with Jones reagent (20 ml). The excess reagent is decomposed with methanol. The solids are removed by filtration. The filtrate is concentrated to a green oil which is purified by flash chromatography on silica gel to give 17β-cyclopropyloxy-androst-4-en-3-one (11.0 g, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05486511 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-34faa9f419f842a58f91b1e31abfa3e4 |
| Source note | uspto-grants-1996_01 |