反应详情

温度

230 °C

A mixture of 1.9 g of 2-[3-(trifluoromethyl)phenyl]ethylamine and 1.6 g of 4-chloro-6-methylfuro[2,3-d]pyrimidine was heated for ten minutes at 230° C. The mixture was then cooled and the product extracted in ethyl acetate/water. The organic phase was separated, washed with water, dried over magnesium sulfate, filtered, and concentrated. The residue was chromatographed on a silica column using toluene and acetone as eluent. Yield 0.97 g. M.P. 119° C.

1. temperatureThe mixture was then cooled
2. extractionthe product extracted in ethyl acetate/water
3. customThe organic phase was separated
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was chromatographed on a silica column