1-Phenylpiperazine → HCID 18993050, compound

Participants

Reaction Steps

A mixture of 2-[4-(4-chlorobutoxy) phenyl]-1H-benzimidazole (Example C) (0.25 g) and 1-phenylpiperazine (0.70 g) is stirred at 110° C. in dimethylformamide (20 mL) for 6 hours. The solvent is evaporated and the residue is purified by chromatography on silica gel eluting with 100:8:1 dichloromethane: ethanol: 0.880 aqueous ammonia to give 0.15 g of the title compound as a brown solid; mp 193°-196° C.

Provenance & Evidence