Triethylamine → HCID 67746822, compound

Participants

Reaction Steps

A mixture of 2-(4-bromophenyl)-1H-benzimidazole (Example F) (8.08 g), 1-but-3-enyl-4-phenylpiperazine (Example G) (8.0 g), palladium acetate (0.66 g), tri-o-tolylphosphine (1.8 g) and triethylamine (7.05 g) in acetonitrile (100 mL) is stirred at reflux for 2 hours. The mixture is cooled and filtered through Celite. The filtrate is evaporated to leave a brown solid. This solid is purified by MPLC on silica gel eluting with 100:8:1 dichloromethane: ethanol: 0.880 aqueous ammonia to give 1.84 g of the title compound as a white solid; mp 140°-145° C.

Provenance & Evidence