HCID 67746822, compound → HCID 18993041, compound

Participants

Reaction Steps

(Z)-2-[4-[4-(4-Phenyl-1-piperazinyl)-1-butenyl]phenyl]-1H-benzimidazole (Example 21) (0.5 g) is hydrogenated with 5% palladium on carbon (0.1 g) in methanol (10 mL) and filtered. The filtrate is evaporated and the residue is purified by MPLC on silica gel eluting with 100:8:1 dichloromethane: ethanol:0.880 aqueous ammonia to give 0.31 g of the title compound as a white solid; mp 239°-243° C.

Provenance & Evidence