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O-Phenylenediamine → Methyl 4-(1H-benzo[d]imidazol-2-yl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Phenylenediamine | HCID 7243 | — |
| 反応物 | Methyl 4-Formylbenzoate | HCID 15294 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 4-(1H-benzo[d]imidazol-2-yl)benzoate | HCID 2328806 | 19% |
反応手順
A mixture of 1,2-diaminobenzene (6.59 g), methyl 4-formylbenzoate (10.0 g) and sodium bisulfite (6.60 g) in methanol (500 mL) is stirred at reflux for 6 hours. The mixture is filtered and the solvent evaporated to leave a yellow solid. This solid is recrystallized from ethyl acetate/ethanol to give 2.92 g of the title compound as an oil-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05486517 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-0333e4b13f7e4467885533976d1c5c5b |
| 出典メモ | uspto-grants-1996_01 |