HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Phenylenediamine → 2-(4-Bromophenyl)benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Bromophenyl)benzimidazole | HCID 286182 | 71.3% |
Reaction Steps
Sodium bisulfite (14.4 g) is added to 4-bromobenzaldehye (17.1 g) in ethanol (100 mL) and the mixture stirred at reflux for 15 minutes. 1,2-Diaminobenzene (10 g) is added and the mixture stirred at reflux for 16 hours. The solvent is evaporated and the residue is washed with water and ethanol to afford 18.0 g of the title compound as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05486517 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-692ad1c1884a401f89e25912f9826ed9 |
| Source note | uspto-grants-1996_01 |