1-(4-Sulfanylphenyl)ethan-1-one → HCID 19935802, compound

HRID 37555Notes

Reaction equation

HRID 37555 reaction equation
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.Cl.I[C:13]1[CH:14]=[C:15]([C:19]2([O:29][CH3:30])[CH2:23][CH2:22][N:21]([CH2:24][C:25]([F:28])([F:27])[F:26])[CH2:20]2)[CH:16]=[CH:17][CH:18]=1>>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([S:1][C:13]2[CH:14]=[C:15]([C:19]3([O:29][CH3:30])[CH2:23][CH2:22][N:21]([CH2:24][C:25]([F:28])([F:27])[F:26])[CH2:20]3)[CH:16]=[CH:17][CH:18]=2)=[CH:3][CH:4]=1)(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 47131801-(4-Sulfanylphenyl)ethan-1-oneHCID 19935829HCID 19935829, compound

Product 1

HCID 19935802HCID 19935802, compoundYield 75%

Procedure

Using an analogous procedure to that described in Example 10, 4'-mercaptoacetophenone was reacted with 3-(3-iodophenyl)-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine hydrochloride to give 3-[3-(4-acetylphenylthio)phenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine as a gum in 75% yield.

Sources & evidence

ORD record
ord-0aa4cc2c37d44ac295add0281651fdf9
Source dataset
uspto-grants-1995_05
Patent number
US05420298

Reaction notes

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