Methyl iodide → HCID 19935870, compound

HRID 37558Notes

Reaction equation

HRID 37558 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][C:8]([OH:18])([C:11]2[CH:12]=[C:13]([S:16][CH3:17])[S:14][CH:15]=2)[CH2:7]1)=[O:5])[CH3:2].[CH3:19]I>>[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][C:8]([O:18][CH3:19])([C:11]2[CH:12]=[C:13]([S:16][CH3:17])[S:14][CH:15]=2)[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 199358201-Ethoxycarbonyl-3-hydroxy-3-(2-methylthiothien-4-yl)pyrrolidine

Product 1

HCID 19935870HCID 19935870, compoundYield 75%

Procedure

Using an analogous procedure to that described in the second paragraph of the portion of Example 1 which is concerned with the preparation of starting materials, 1-ethoxycarbonyl-3-hydroxy-3-(2-methylthiothien-4-yl)pyrrolidine was reacted with methyl iodide to give 1-ethoxycarbonyl-3-methoxy-3-(2-methylthiothien-4-yl)pyrrolidine as an oil in 75% yield.

Sources & evidence

ORD record
ord-07b1ec3f841f4e3a95970065db1360f2
Source dataset
uspto-grants-1995_05
Patent number
US05420298

Reaction notes

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