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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 37559Generated: October 29, 2026

Hydroxyamine hydrochloride → 3-{2-[4-(1-Hydroxyiminoethyl)phenylthio]thien-5-yl}-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine

https://huagongshe.com/reaction/37559

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydroxyamine hydrochlorideHCID 443297—
Reactant3-[2-(4-Acetylphenylthio)thien-5-yl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidineHCID 19935806—
Product3-{2-[4-(1-Hydroxyiminoethyl)phenylthio]thien-5-yl}-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidineHCID 8674869763%

Reaction Steps

Using an analogous procedure to that described in Example 27, 3-[2-(4-acetylphenylthio)thien-5-yl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine was reacted with hydroxylamine hydrochloride to give 3-{2-[4-(1-hydroxyiminoethyl)phenylthio]thien-5-yl}-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine as a gum in 63% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05420298
Source datasetuspto-grants-1995_05
ORD IDord-a465c113fb3143f7b0110f62b2c0a2d9
Source noteuspto-grants-1995_05