HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 375641Generated: October 28, 2026
4-Toluenesulfonyl chloride → HCID 18993251, compound
https://huagongshe.com/reaction/375641
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 1-Methylindole | HCID 11781 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | HCID 18993232 | HCID 18993232 | — |
| Product | HCID 18993251 | HCID 18993251 | — |
Reaction Steps
A mixture of 4-azidomethylphenylsulfonyl azide (2.93 g, 12.3 mmol), prepared by reaction of p-toluenesulfonyl chloride with N-bromosuccinimide followed by sodium azide, and 1-methylindole was heated at 55° C. for 6 hours. Pure 1-methyl-3-[4-(azidomethyl)phenylsulfonylamino]indole was obtained by chromatography on silica gel (1:1 CH2Cl2 /hexanes, then CH2Cl2, then 1.5% methanol/CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05486525 |
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| Source dataset | uspto-grants-1996_01 |
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| ORD ID | ord-522686effa564459919e0cddf9448c5c |
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| Source note | uspto-grants-1996_01 |
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