Thionyl Chloride → HCID 18993213, compound

HRID 375643Notes

Reaction equation

HRID 375643 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[CH:12][C:11](C(OC)=O)=[C:10]2[C:6]=1[CH:7]=[CH:8][NH:9]2)=[O:4].[F:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[CH3:28])[C:22](O)=[O:23].S(Cl)(Cl)=O.ClCC1C=CC(C(Cl)=O)=CC=1>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[C:7]([C:22](=[O:23])[C:21]1[CH:25]=[CH:26][C:27]([CH3:28])=[C:19]([F:18])[CH:20]=1)=[CH:8][NH:9]2)=[O:4]

Participants

5

Reactant 4

HCID 24386Thionyl ChlorideHCID 676873-Fluoro-p-toluic acidHCID 701364-(Chloromethyl)benzoyl chlorideHCID 10633375HCID 10633375, compound

Product 1

HCID 18993213HCID 18993213, compound

Procedure

The desired compound was prepared according to the method of Example 90, step 2, except substituting 4-methoxycarbonylindole for 4,7-dimethoxycarbonylindole, and substituting 3-fluoro-4-methylbenzoyl chloride, prepared by reaction of 3-fluoro-4-methylbenzoic acid with thionyl chloride, for 4-chloromethylbenzoyl chloride.

Sources & evidence

ORD record
ord-452463c85d9c433ab7f874d30e762c08
Source dataset
uspto-grants-1996_01
Patent number
US05486525

Reaction notes

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