HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (2RS,3SR)-3-(3-benzyloxyphenyl)-1-ethoxycarbonyl-3-methoxy-2-methylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 1-(Benzyloxy)-3-bromobenzene | HCID 2756638 | — |
| Reactant | Ethyl 2-methyl-3-oxopyrrolidine-1-carboxylate | HCID 14664486 | — |
| Product | (2RS,3SR)-3-(3-benzyloxyphenyl)-1-ethoxycarbonyl-3-methoxy-2-methylpyrrolidine | HCID 19935814 | 65% |
Reaction Steps
Using an analogous procedure to that described in the portion of Example 1 which is concerned with the preparation of starting materials, 3-benzyloxybromobenzene was reacted with 1-ethoxycarbonyl-2-methylpyrrolidin-3-one (J. Med. Pharm. Chem., 1962, 5, 755) and the resultant product was reacted with methyl iodide to give (2RS,3SR)-3-(3-benzyloxyphenyl)-1-ethoxycarbonyl-3-methoxy-2-methylpyrrolidine in 65% yield as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420298 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-8debd797168d40c387acc85f5e642d3d |
| Source note | uspto-grants-1995_05 |