HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 178447832, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-Bromo-3,4,5-trifluorobenzene | HCID 611409 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Reactant | HCID 178447830 | HCID 178447830 | — |
| Catalyst | Zinc bromide | HCID 10421208 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 178447832 | HCID 178447832 | — |
Reaction Steps
25 ml of butyllithium (15% in hexane) are added dropwise at -70° C. to a solution of 15 g of 4-(trans-4-n-propylcyclohexyl)-2-fluoro-4'-bromobiphenyl in 50 ml of THF and a cooled solution of 4.5 g of ZnBr2 in 25 ml of THF is added after 30 min. After addition of 8.5 g of 1-bromo-3,4,5-trifluorobenzene in 75 ml of THF and 0.6 g of PdCl2 -dppf, the mixture is allowed to come to room temperature. After stirring for 24 h, the mixture is poured into 100 ml of saturated NH4Cl solution and worked up as usual. 4"-(trans-4-n-Propylcyclohexyl)-2",3,4,5-tetrafluoroterphenyl is obtained, C 148 N 233 I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05487845 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-fda1d91d0a1a47f3abfa1ad042da2448 |
| Source note | uspto-grants-1996_01 |