HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(p-Ethoxyphenyl)-2-(3,4,5-trifluorophenyl)ethene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Ethoxystyrene | HCID 79570 | — |
| Reactant | Tri-o-tolylphosphine | HCID 80271 | — |
| Reactant | 1-Bromo-3,4,5-trifluorobenzene | HCID 611409 | — |
| Catalyst | palladium(I)acetate | HCID 9793925 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(p-Ethoxyphenyl)-2-(3,4,5-trifluorophenyl)ethene | HCID 54315374 | — |
Reaction Steps
A mixture of 10.5 g of 1-bromo-3,4,5-trifluorobenzene, 7.4 g of p-ethoxystyrene, 0.25 g of Pd acetate, 0.6 g of tri-o-tolylphosphine, 7 g of triethylamine and 125 ml of acetonitrile is heated at reflux until completion of the reaction. Customary working-up gives 1-(p-ethoxyphenyl)-2-(3,4,5-trifluorophenyl)ethene (C 76 I), which is hydrogenated on PD-C (5%) in THF to give 1-(p-ethoxyphenyl)-2-(3,4,5-trifluorophenyl)ethane, C 45 I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05487845 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-da8a464857a941818691b76683c84de1 |
| Source note | uspto-grants-1996_01 |