反应详情

A mixture of 2-hydroxy-1-naphthaldehyde (172 mg, 1 mmol), 2-cyanothioacetamide (110 mg, 1.1 mmol), N,N-diethylaminoethanol (23 mg, 0.2 mmol) and 15 ml ethanol is stirred for 30 min at reflux under nitrogen. Then the mixture is chilled, the precipitate filtered, washed with ice-cooled ethanol and dried in a vacuum-oven. Thus an almost pure title compound is obtained in 85% yield (1080 mg). Recrystallization from ethanol furnishes very pure samples.

1. temperatureat reflux under nitrogen
2. temperatureThen the mixture is chilled
3. filtrationthe precipitate filtered
4. washwashed with ice-
5. temperaturecooled ethanol
6. customdried in a vacuum-oven