HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 1-ethyl-4-chloro-6-methoxy-1H-pyrazolo[3,4-b]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | N-(1-ethylpyrazol-5-yl)-5-methoxyanthranilic acid | HCID 19592240 | — |
| Product | 1-ethyl-4-chloro-6-methoxy-1H-pyrazolo[3,4-b]quinoline | HCID 19592212 | — |
Reaction Steps
A mixture of N-(1-ethylpyrazol-5-yl)-5-methoxyanthranilic acid (27.5 g, 0.105 mol) and POCl3 (60 ml) was refluxed overnight. The reaction mixture was poured into ice-water, basified with NH4OH and the solid which formed was collected by filtration to afford 20 g of 4-chloro-1-ethyl-6-methoxy-1H-pyrazolo[3,4-b]quinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05488055 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-7635fe0296304b05aad2ff529bb07724 |
| Source note | uspto-grants-1996_01 |