反应详情

温度

110 °C

A mixture of 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]quinoline (1 g), DMSO (3 ml) and adamantylmethylamine (1 g) was heated at 110° C. overnight. The reaction mixture was poured into water, and a precipitate formed which was collected by filtration and dried to afford the product as a free base. The free base was treated with methanesulfonic acid/methanol, the methanol was evaporated and the salt was recrystallized from 2-propanol to afford 290 mg of 1-ethyl-N-(adamantylmethyl)-1H-pyrazolo[3,4-b]quinolin-4-amine.CH3SO3H, m.p. 310° C.

1. customa precipitate formed which
2. filtrationwas collected by filtration
3. customdried
4. customto afford the product as a free base
5. customthe methanol was evaporated
6. customthe salt was recrystallized from 2-propanol