Ethanol → HCID 21217692, compound

Participants

Reaction Steps

A mixture of 1-ethyl-6-methoxycarbonyl-N-(cyclohexylmethyl)-1H-pyrazolo[3,4-b]quinoline-4-amine (1.4 g), ethanol (90 mL), KOH (2 g) and water (10 mL) was stirred at room temperature overnight. The reaction mixture was evaporated and the residue was partitioned between CH2Cl2 and water. The aqueous layer was separated, acidified with acetic acid and the solid which formed was collected by filtration and dried. The solid was recrystallized from hot acetic acid (50 mL) to afford 1.0 g of 1-ethyl-6-carboxy-N-(cyclohexylmethyl)-1H-pyrazolo[3,4 -b]quinolin-4-amine. HOAc, m.p. 240° C.

Provenance & Evidence