Potassium Hydroxide → HCID 54030496, compound

HRID 376026Notes

Reaction equation

HRID 376026 reaction equation
[OH-].[K+].F[C:4]1[C:5]([F:17])=[C:6]([F:16])[C:7]([F:15])=[C:8]2[C:13](=[O:14])[O:12]C(=O)[C:9]=12.[F:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][OH:24])=[CH:21][CH:20]=1>O>[F:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][O:24][C:4]2[C:5]([F:17])=[C:6]([F:16])[C:7]([F:15])=[C:8]([CH:9]=2)[C:13]([OH:12])=[O:14])=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 680224-Fluorobenzylic alcoholHCID 69545Tetrafluorophthalic anhydride

Product 1

HCID 54030496HCID 54030496, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

8.4 g (0.15 mol) of potassium hydroxide are dissolved in 30 g of water, and 6.6 g (30mmol) of tetrafluorophthalic anhydride and 30 g (0.238 mol) of 4-fluorobenzyl alcohol are added. The mixture is heated at 100° C. for 12 hours after which the procedure as described in Example 2 is followed. It is advantageous not to allow the pH to fall below 3 prior to the extraction steps. This method gives 4.2 g (14 mmol, corresponding to 47%) of (4-fluorobenzyloxy) trifluorobenzoic acid (purity 80-85%).

Workup

  1. extractionto the extraction steps

Sources & evidence

ORD record
ord-90500409cca04adbae79a7055d463b14
Source dataset
uspto-grants-1996_01
Patent number
US05488152

Reaction notes

Loading…