Fumaric Acid → L-Aspartic Acid

HRID 376028Notes

Reaction equation

HRID 376028 reaction equation
C(O)(=O)/C=C/C(O)=O.[NH2:9][C@H:10]([C:15]([O-:17])=[O:16])[CH2:11][C:12]([O-:14])=[O:13].[NH4+].[NH4+]>O>[NH2:9][C@H:10]([C:15]([OH:17])=[O:16])[CH2:11][C:12]([OH:14])=[O:13]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 86590683Ammonium Aspartate

Product 1

HCID 5960L-Aspartic AcidYield 42.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
20 °C

Procedure

1.79 g of fumaric acid, with 25 g of water, were charged into a 100 ml Erlenmeyer flask. 24.8 g of the 37.27% w/w ammonium aspartate solution (0.0617 mol) of Example 1 were then added thereto. The liquid/solid mixture was then stirred for 1 h at a temperature of 20° C. After filtering, washing and drying, 3.49 g of L-aspartic acid were obtained.

Workup

  1. filtrationAfter filtering
  2. washwashing
  3. customdrying

Sources & evidence

ORD record
ord-553ccfd610ae47a195dc0e34a8c68a86
Source dataset
uspto-grants-1996_01
Patent number
US05488155

Reaction notes

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