p-METHYLACETOPHENONE → HCID 21469988, compound

Participants

Reaction Steps

A mixture of p-methylacetophenone (2.68 g. 0.02M) and hypophosphorous acid (90%, 1.45 g. 0.02M) is heated on a steam bath for 12 hours. The reaction mixture is poured into ice-water and the organic material is extracted with ethyl acetate. Evaporation and co-evaporation with toluene gives a white solid which is crystallised from chloroform/hexane. There is obtained 1-hydroxy-1-p-tolylethylphosphonous acid, m.p. 115° C.

Provenance & Evidence