Triethylamine → HCID 18991701, compound

Participants

Reaction Steps

To a mixture of 5.0 g (9.2 mmol) of 4-[5-[4-(aminoiminomethyl)phenoxy]pentyloxy]-N,N-bis(1-methylethyl)benzamide monohydrochloride in 10 ml of methylene chloride is added 3.3 g (18.4 mmol) of isonicotinoyl chloride hydrochloride and 5.0 ml of triethylamine. The mixture is stirred at room temperature for 24 hours and purified by chromatography on silica gel with 80% ethyl acetate/hexane as the eluent to obtain 4-[5-[4-[(isonicotinoylimino)aminomethyl]phenoxy]pentyloxy]-N,N-bis(1 -methylethyl)benzamide:

Provenance & Evidence