Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (E)-2-(fluoromethylene)-4-(p-fluorophenyl)butan-1-ol | HCID 10943450 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Mofegiline | HCID 6437850 | — |
Reaction Steps
Combine oxalyl chloride (25.2 g, 0.198 mol) and toluene (200 mL). Cool to -5° C. Add N,N-dimethylformamide (15.0 g, 0.21 mol) as a solution in toluene (20 mL). Warm to 25° C. After 30 minutes, add a solution of (E)-2-(fluoromethylene)-4-(p-fluorophenyl)butan-1-ol (24.7 g, 30% by weight in toluene, 0.124 mol). After 18 hours, add water (500 mL) and stir for 30 minutes. Separate the organic layer, dry over Na2SO4, filter, and evaporate in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05488188 |
|---|
| Source dataset | uspto-grants-1996_01 |
|---|
| ORD ID | ord-0e0601195cd24b1c8b1d925c720d7e13 |
|---|
| Source note | uspto-grants-1996_01 |
|---|
