Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | (E)-1-chloro-2-(fluoromethylene)-4-(p-fluorophenyl)butane | HCID 9815806 | — |
| Reactant | Sodium Diformylamide | HCID 10877056 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Mofegiline | HCID 6437850 | — |
Reaction Steps
Combine sodium diformylamide (70 lb) and acetonitrile (903 lb). With agitation, add N,N-dimethylformamide (119 lb). Add a solution of (E)-1-chloro-2-(fluoromethylene)-4-(p-fluorophenyl)butane (126 lb) in toluene. Warm to 80° C. After 6 hours, add a 10% by weight solution of sodium chloride in water (1168 lb). Agitate for 15 minutes, separate the layers. Remove the organic layer to give the title compound as a solution in acetonitrile/N,N-dimethylformamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05488188 |
|---|
| Source dataset | uspto-grants-1996_01 |
|---|
| ORD ID | ord-522700bca1c84d56a60c5c77989b64b8 |
|---|
| Source note | uspto-grants-1996_01 |
|---|
