HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,8-Diamino-4-phosphonomethyl-oct-3-enoic acid dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 8-(N-benzyloxycarbonylamino)-4-diethylphosphonomethyl-2-formylamino-oct-3-enoic acid methyl ester | HCID 54234013 | — |
| Product | 2,8-Diamino-4-phosphonomethyl-oct-3-enoic acid dihydrochloride | HCID 86747669 | — |
Reaction Steps
0.5 g (1.0 mmol) of 8-(N-benzyloxycarbonylamino)-4-diethylphosphonomethyl-2-formylamino-oct-3-enoic acid methyl ester is heated under reflux in 5.0 ml of 6N hydrochloric acid for 6 hours. Concentration to dryness by evaporation yields 2,8-diamino-4-phosphonomethyl-oct-3-enoic acid dihydrochloride in the form of a rubber-like solid which is recrystallised from acetonitrile; m.p. 128° (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05488140 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-fbc2be0b0d424015a829609c489377b4 |
| Source note | uspto-grants-1996_01 |