Methyl iodide → Methyl 2-isopropyl-alpha-[(Z)-methoxy methylene]-4[(E)-styryl]-5-thiazolacetate

Participants

Reaction Conditions

Reaction Steps

The product of Step G was dissolved in 20 ml of acetone and then 3 ml of methyl iodide and 4 g of potassium carbonate were added. The mixture was stirred for 16 hours at 20° C. After bringing the mixture to dryness, the residue was chromatographed on silica, eluting with a hexane--ethyl acetate mixture (8-2) to obtain 1.3 g of the desired product. Thin layer chromatography; Rf=0.20 [eluant: hexane--ethyl acetate (8-2)].

Provenance & Evidence