HCID 53676203, compound → HCID 54519196, compound

HRID 376119Notes

Reaction equation

HRID 376119 reaction equation
C([O:3][C:4](=[O:17])[CH:5]([NH2:16])[CH:6]=[C:7]([CH2:11][P:12]([OH:15])([OH:14])=[O:13])[CH2:8][CH2:9][F:10])C>O>[NH2:16][CH:5]([CH:6]=[C:7]([CH2:11][P:12]([OH:14])([OH:15])=[O:13])[CH2:8][CH2:9][F:10])[C:4]([OH:17])=[O:3]

Participants

3

Reactant 1

HCID 53676203HCID 53676203, compound

Product 1

HCID 54519196HCID 54519196, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.5 g (1.86 mmol) of 2-amino-6-fluoro-4-phosphonomethyl-hex-3-enoic acid ethyl ester are heated under reflux in 4 ml of water for 17 hours. The reaction mixture is concentrated by evaporation and separated with water on a strongly acidic ion-exchanger (Dowex 50W×8; It⊕ form). 2-amino-6-fluoro-4-phosphonomethyl-hex-3-enoic acid having a melting point of 160°-162° C. (decomp.) is obtained.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. customseparated with water on a strongly acidic ion-exchanger (Dowex 50W×8; It⊕ form)

Sources & evidence

ORD record
ord-353145bdf5c14ca4bc8e1e7cedfb127a
Source dataset
uspto-grants-1996_01
Patent number
US05488140

Reaction notes

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