反应详情

温度

100 °C

45.1 g of the ketone compound thus obtained, 50.3 g of 3,4-dichlorobenzyl chloride and 15.8 g of sodium hydroxide were mixed, heated with stirring at 100° C. for 6 hours. The reaction solution was left to cool to room temperature and then extracted by an addition of ethyl acetate and water. The organic layer was post-treated by a conventional method. Then, the product was purified by silica gel column chromatography (hexane/ethyl acetate=50/1) to obtain 65.0 g (yield: 85%) of 4-(3,4-dichlorophenyl)-3-(2-fluoro-4-biphenylyl)-2-butanone.

1. temperatureheated
2. waitThe reaction solution was left
3. temperatureto cool to room temperature
4. extractionextracted by an addition of ethyl acetate and water
5. additionThe organic layer was post-treated by a conventional method
6. customThen, the product was purified by silica gel column chromatography (hexane/ethyl acetate=50/1)