Chloroform → HCID 18397091, compound

Participants

Reaction Steps

To 10 ml of a chloroform solution of 0.19 g (0.4 mmol) of the (R)1-trifluoromethyl-6-ethoxyhexyl 6-benzyloxy-3,4-dihydro-2-naphthalenecarboxylate obtained in the first step was added 0.1 ml (0.4 mmol) of iodotrimethylsilane in a nitrogen atmosphere with stirring, and the mixture was reacted at room temperature for two and a half hours with stirring. Then, 8 ml of methanol was added, and the mixture was rapidly concentrated at room temperature under reduced pressure. The concentrate was separated by column chromatography, to obtain 0.64 g of (R)1-trifluoromethyl-6-ethoxyhexyl 6-hydroxy-3,4-dihydro-2-naphthalenecarboxylate as a crude product. The 1H-NMR data of this compound are described below. 1H-NMR (CDCl3), δ (ppm)

Provenance & Evidence