Chloroform → HCID 18397096, compound

Participants

Reaction Steps

To 3.1 ml of a chloroform solution of 0.82 g (1.9 mmol) of the (R)1-trifluoromethylpentyl 6-benzyloxy-1-fluoro-3,4-dihydro-2-naphthalenecarboxylate obtained in the third step was dropwise added 134 μl (0.95 mmol) of iodotrimethylsilane, and they were reacted at room temperature for 30 minutes in a nitrogen atmosphere with stirring. Then, 10 ml of methanol was added to terminate the reaction. The reaction mixture was separated by column chromatography, to obtain 0.24 g of (R)1-trifluoromethylpentyl 6-hydroxy-1-fluoro-3,4-dihydro-2-naphthalenecarboxylate (yield: 37%). The 1H-NMR data of this compound are described below.

Provenance & Evidence