HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 376215Generated: November 1, 2026
Ethyl cyanoacetate → 5'-(2-Cyano-2-ethoxycarbonylvinyl)-1,3,3-trimethylspiro-[indoline-2,3'-[3H]-naphtho[2,1-b][1,4]oxazine]
https://huagongshe.com/reaction/376215
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | 5'-Formyl-1,3,3-trimethylspiro[indoline-2,3'-[3H]-naphtho[2,1-b][1,4]oxazine] | HCID 15305689 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5'-(2-Cyano-2-ethoxycarbonylvinyl)-1,3,3-trimethylspiro-[indoline-2,3'-[3H]-naphtho[2,1-b][1,4]oxazine] | HCID 53658548 | — |
Reaction Steps
To a solution of 0.18 g (1.5 mmol) of ethyl cyanoacetate in a minimum quantity of ethanol are added 0.36 g (1 mmol) of the product of Example 1 and then two drops of piperidine. The mixture is heated at 60° C. until a precipitate appears. The precipitate obtained is filtered off, washed with ethanol and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06019914 |
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| Source dataset | uspto-grants-2000_02 |
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| ORD ID | ord-b382f62596194f3db208fbcf87334264 |
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| Source note | uspto-grants-2000_02 |
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