1,3,4-Thiadiazol-2-amine → HCID 19361559, compound

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Reaction Steps

A mixture of 2-chloromethylpyridine (1.75 g, 0.0137 M) and 2-amino-1,3,4-thiadiazole (1.09 g, 0.0108 M) in 20 mL ethyl alcohol was refluxed for 20 hours. The reaction mixture was cooled to room temperature and filtered. The precipitate was washed with ethyl acetate and dried to yield 0.680 g of the title compound. MP=187-189° C. 1H-NMR (DMSO-d6) δ 10.6 (br s, 1H), 9.0 (s, 1H), 8.5 (d, 1H), 7.9 (m, 1H), 7.48 (d, 1H), 7.38 (m, 1H), 5.7 (s, 2H). 13C-NMR (DMSO-d6) δ 167.7, 153.0, 149.3, 145.0, 137.4, 123.4, 122.4, 54.0. Mass spectrum: m/e=193 (p+1).

Provenance & Evidence