Hydrochloric Acid → HCID 22009524, compound

Participants

Reaction Steps

5.5 g of 4-difluoromethoxy-3-(2-methyl-3-butyn-2-yloxy) benzaldehyde are heated to reflux with 7.2 g of cesium fluoride with nitrogen aeration for 12 h in 30 ml of N,N-diethylaniline. The mixture is stirred into 300 ml of 4 N hydrochloric acid after cooling, the resulting emulsion is extracted three times with 50 ml of ethyl acetate, and the organic extracts are combined, dried over ignited potassium carbonate and evaporated in vacuo. The residue is chromatographed on silica gel using toluene. After the evaporation of the appropriate fractions, the title compound is obtained as an oil.

Provenance & Evidence