Diisopropylamine → HCID 19361670, compound

Participants

Reaction Steps

A mixture of 2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(2-pyridyl)furan, (0.5 g) example 2, in CH2Cl2 (3 ml) and diisopropylamine(21 ul) and NBS (0.320 g) were stirred for 20 mins. at room temperature. The reaction mixture was quenched with Na2CO3, extracted with CH2Cl2 dried with sodium sulfate and evaporated in vacuo to afford the title compound as a beige solid in 63% yield. 1H NMR (300 MHz, CDCl3): δ 1.6 (m, 2H), 2.0-1.8 (m, 6H), 3.90 (s, 3H), 4.95 (m, 1H), 7.05 (dd, 1H), 7.23 (m, 2H), 7.43 (m, 2H), 7.85 (dd, 2H), 8.5 (dd, 1H).

Provenance & Evidence