Dimethylamine → HCID 19361727, compound

HRID 376275Notes

Reaction equation

HRID 376275 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8](F)[N:7]=1.[CH3:13][NH:14][CH3:15].C(O)C>>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[N:7]=[C:8]([N:14]([CH3:15])[CH3:13])[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 702EthanolHCID 10559050208111-44-8

Product 1

HCID 19361727HCID 19361727, compound

Conditions

Temperature
100 °C

Procedure

0.60 g of 2-[1,3]dioxolan-2-yl-6-fluoropyridine (3.55 mmol) and 2.50 ml of dimethylamine at 33% in ethanol (17.7 mmol) are mixed and then the mixture is heated at the temperature of 100° C. for 12 hours. After evaporation under vacuum, the residue is taken up in chloroform, the mixture is washed with water, dried over magnesium sulfate, filtered and the chloroform is evaporated under vacuum. The title product is obtained in the form of a yellow oil which is used in the next stage without further purification.

Workup

  1. customAfter evaporation under vacuum
  2. washthe mixture is washed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customthe chloroform is evaporated under vacuum

Sources & evidence

ORD record
ord-ee1a931f0a58437eb81d608819e5a7f8
Source dataset
uspto-grants-2000_02
Patent number
US06020345

Reaction notes

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