HCID 19361724, compound → HCID 178504272, compound

Participants

Reaction Steps

7 g of Raney Nickel are added to a solution of 7 g of 2-benzyloxy-6-(2-trimethylsilanyl-ethoxymethoxy-methyl)pyridine in 75 ml of ethanol saturated with hydrogen. The suspension is stirred vigorously under a low hydrogen pressure at room temperature for 1 hour 30 minutes. The solid in suspension is removed by filtration on celite and then the ethanol is evaporated off. The title product is isolated by chromatography on a silica column (eluent: dichloromethane/methanol; 98:2). 4 g of a colorless oil are recovered.

Provenance & Evidence