Tetrabutylammonium Fluoride → HCID 10535231, compound

Participants

Reaction Conditions

Reaction Steps

3 g of 2-[6-(2-trimethylsilanyl-ethoxymethoxy-methyl)pyridin-2-yl]pyrrole-1-carboxylic acid tert-butyl ester (7.41 mmol) are added to a solution of 3 ml of 1.1 M tetrabutylammonium fluoride in tetrahydrofuran, 45 ml of tetrahydrofuran and 5 ml of hexamethylphosphoramide, containing 10 g of molecular sieve (4 angstrom). The mixture is stirred at 45° C. under argon for 8 hours. After filtration of the insoluble matter on celite, the tetrahydrofuran is evaporated off. The title product is purified by chromatography on a silica column (eluent: dichloromethane/ethyl acetate; 99:1). 0.50 g of a white solid is recovered.

Provenance & Evidence