Water → HCID 10728384, compound

HRID 376286Notes

Reaction equation

HRID 376286 reaction equation
[S:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[O:16][CH2:15][CH2:14][O:13]2)[N:7]=1.O>C1C=CC=CC=1.O.OO.[Ni]>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[O:16][CH2:15][CH2:14][O:13]2)[N:7]=1

Participants

5

Reactant 2

HCID 962WaterHCID 19361766HCID 19361766, compound

Product 1

HCID 10728384HCID 10728384, compoundYield 31.5%

Reagents, catalysts & solvents 2

HCID 7131114086676-91-7CatalystHCID 241BenzeneSolvent

Procedure

10 g of nickel peroxide hydrate are added in 1 g portions over 20 hours to a solution of 1.33 g of 2-(4,5-dihydrothiazol-2-yl)-6-[1,3]dioxolan-2-yl-pyridine (5.62 mmol) in 50 ml of benzene maintained under reflux with removal of the water formed continuously. The insoluble matter is removed by filtration on celite and then the solvent is evaporated off. The title product is isolated by chromatography on a silica column (eluent: chloroform/ethyl acetate; 85:15). 0.42 g of a white solid is recovered.

Workup

  1. temperaturemaintained
  2. customformed continuously
  3. customThe insoluble matter is removed by filtration on celite
  4. customthe solvent is evaporated off

Sources & evidence

ORD record
ord-11bdf41f2436494abf22cb4bab359661
Source dataset
uspto-grants-2000_02
Patent number
US06020345

Reaction notes

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