反应详情

A solution of the title product of Example 10 (2.0 grams, 8.5 mmoles) and thionyl chloride (2.03 g, 17.1 mmoles) in toluene (50 ml) is heated at reflux for one hour. After cooling, the mixture is evaporated. Chromatography of the residue over silica gel using mixtures of ethyl acetate and hexane as eluents gives the title compound.

1. temperatureat reflux for one hour
2. temperatureAfter cooling
3. customthe mixture is evaporated