Potassium borohydride → HCID 10647006, compound

Participants

Reaction Steps

0.687 g of (4-aminomethyl-4-fluoropiperidin-1-yl)-(3-chloro-4-fluorophenyl)methanone (2.38 mmol) and 0.371 g of 6-furan-2-yl-pyridine-2-carbaldehyde (2.38 mmol) are mixed in 25 ml of toluene. The solution is heated under reflux under a nitrogen atmosphere for 2 hours, removing the water formed continuously. The toluene is evaporated off, the residue is taken up in 25 ml of methanol and then 0.257 g of potassium borohydride (4.51 mmol) is added in portions. The reaction mixture is stirred for 5 hours at room temperature and then the methanol is evaporated off. The residue is taken up in chloroform, the organic phase is washed with water and then with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, filtered and concentrated under vacuum. The title product is isolated by chromatography on a silica column (eluent: chloroform/methanol; 98:2). 0-65 g of a yellow oil is obtained.

Provenance & Evidence