反应详情

To a solution of the title product of Example 18 (500 mg, 2.14 mmoles) in ethanol (10 ml) is added a solution of sodium borohydride (80.8 mg, 2.14 mmoles) in water (1 ml). After disappearance of starting material as judged by TLC, excess reagent is destroyed by addition of acetic acid, and the mixture concentrated. The residue is partitioned between diethyl ether and water, the organic layer dried over sodium sulfate, filtered, and evaporated. Chromatography of the residue over silica gel using mixtures of ethyl acetate and hexane as eluents affords the title compound.

1. customis destroyed by addition of acetic acid
2. concentrationthe mixture concentrated
3. customThe residue is partitioned between diethyl ether and water
4. dry with materialthe organic layer dried over sodium sulfate
5. filtrationfiltered
6. customevaporated