反应详情

To a suspension of the alcohol of Step 1 (100 mg, 0.354 mmol) in benzene (5.0 mL) were added an excess of 2-iodopropane (105 mL) and Ag2CO3 (294 mg, 1.06 mmol). After a period of 18 h at 45° C., the reaction mixture was filtered over celite and washed with CH2Cl2. After evaporation, the crude compound was purified by flash chromatography (35% to 40% EtOAc) to provide 70 mg of the title compound.

1. filtrationthe reaction mixture was filtered over celite
2. washwashed with CH2Cl2
3. customAfter evaporation
4. customthe crude compound was purified by flash chromatography (35% to 40% EtOAc)