2-Hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)butan-1-one → (1-cyclopropylethoxy)acetic acid 2(R)-methyl-1-(4-(methylsulfonyl)phenyl)butan-1-one-2yl ester

HRID 376354Notes

Reaction equation

HRID 376354 reaction equation
[CH:1]1([CH:4]([O:6][CH2:7][C:8]([OH:10])=[O:9])[CH3:5])[CH2:3][CH2:2]1.O[C:12]([CH3:27])([CH2:25][CH3:26])[C:13]([C:15]1[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=1)=[O:14]>>[CH3:27][C@@:12]([O:9][C:8](=[O:10])[CH2:7][O:6][CH:4]([CH:1]1[CH2:3][CH2:2]1)[CH3:5])([CH2:25][CH3:26])[C:13]([C:15]1[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=1)=[O:14]

Participants

3

Reactant 2

HCID 154806442-Hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)butan-1-oneHCID 221142352-(1-cyclopropylethoxy)Acetic acid

Product 1

HCID 70107480(1-cyclopropylethoxy)acetic acid 2(R)-methyl-1-(4-(methylsulfonyl)phenyl)butan-1-one-2yl ester

Procedure

The title compound was prepared as described in Example 134 Step 2 using (1-cyclopropylethoxy)acetic acid and 2(R) 2-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)butan-1-one from Example 117, Step 3.

Sources & evidence

ORD record
ord-826a835bba7944e5900f7ea0278e7b1a
Source dataset
uspto-grants-2000_02
Patent number
US06020343

Reaction notes

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