反应详情

温度

130 °C

To the mixture of 3-diazo-2,4-(3H, 5H)-furandione (300 mg, 2.38 mmol; Example 207, Step 1) and a-methylcyclopropanemethanol (2.0 mL) was added rhodium acetate (30 mg). The mixture was heated at 130° C. for a period of 18 h. The excess of alcohol was evaporated under reduced pressure and the resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2) to provide 50 mg of the title compound.

1. customThe excess of alcohol was evaporated under reduced pressure
2. customthe resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2)