Acetic Acid → HCID 69946017, compound

HRID 376392Notes

Reaction equation

HRID 376392 reaction equation
Cl.[NH2:2][N:3]=[CH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([O:24]CC)=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[C:7]([F:30])[CH:6]=1.C(O)(=O)C>C(O)C.[OH-].[Na+]>[NH2:2][N:3]=[CH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([OH:24])=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[C:7]([F:30])[CH:6]=1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 69945842HCID 69945842, compound

Product 1

HCID 69946017HCID 69946017, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1.2 g (2.75 mmol) of the ester from Example 69 were stirred overnight at room temperature in a mixture of 20 ml ethanol and 5 ml 2 N aqueous sodium hydroxide solution. It was brought to pH 4 with 2 N acetic acid, and the precipitate of the title compound was filtered with suction, washed successively with water and with acetone, and dried in vacuo at 50° C. Yield: 0.84 g (82%) of a pale yellow powder, m.p. 250° C.

Workup

  1. filtrationthe precipitate of the title compound was filtered with suction
  2. washwashed successively with water and with acetone
  3. customdried in vacuo at 50° C

Sources & evidence

ORD record
ord-3b149aeec57a41de8889c9d9de109c76
Source dataset
uspto-grants-2000_02
Patent number
US06020362

Reaction notes

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